A study -with Rambazole, a novel retinoic acid metabolismblocking agent (RAMBA), determined that 94 per cent of subjects -with moderatetosevere acne treated -with 1 mg of oral Rambazole once daily for 12 consecutive -weeks experienced reduction in total acne lesion count of more than 50 per cent and 35 per cent -were considered "cleisd or almost cleisd.

This study points to the production of this medication on future, since Barrier Therapeutics, Inc. reported positive Phase 2a data for its oral formulation of Rambazole (TM) in the treatment of moderate to severe acne and positive biological activity data for its topical formulation of this product.

Experts explain that a subject must have had more than 90 per cent reduction in total lesion count to be considered “cleisd or almost cleisd”. According to their report, inflammatory and noninflammatory lesions responded equally -well to treatment. There -were no serious effects related to the treatment -with this ne-w component. only some patients of the group in study experienced dryness of skin and lips as nonserious side effects.

Geert Cau-wenbergh, Ph.D., Chairman and Chief Executive officer of Barrier Therapeutics, Inc. explained that “these positive Phase 2a results indicate that oral Rambazole is active in moderate to severe inflammatory acne, and that depending on the outcome of future, full scale clinical trials, this drug may one day fill the need for safe and effective oral treatments for moderate and severe acne. These results further build on our previously announced promising clinical data for oral Rambazole for psoriasis”.